杨晓瑜课题组介绍
| 课题组长（PI） |  |
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| 研究介绍 (Research Interest) | |
本课题组的研究将围绕着有机（合成）化学 这个核心科学（Central Science）展开，具体包括：
1）有机催化的不对称反应 （Asymmetric Organocatalysis）
不对称有机催化相比于过渡金属催化具有催化剂绿色环保来源充足、反应条件温和以及反应方式多样等一系列优点，是近年来不对称催化领域发展的一个热点（2019年被IUPAC评为十大改变世界的化学创新之一）。本课题组现阶段的一个主要研究方向就是利用手性Br?nsted酸类催化剂，利用其作为质子酸催化剂、手性阴离子以及手性配体等多种参与不对称反应的方式，发展新颖、高效的不对称反应。
2）具有生理活性的天然产物及小分子药物（糖缀合物）的合成 （Carbohydrate Chemistry）
糖作为组成生命体的一类重要大分子，相较于蛋白质、DNA等受到的研究却较少，这是由于糖类化合物相比于蛋白质、DNA等具有更加复杂的化学特性，包括其连接的区域选择性、糖苷化反应的立体选择性等。本课题组的一个研究兴趣就是利用催化剂实现糖类分子的高效区域选择性以及立体选择性合成。
3）化学生物学（选择性蛋白质修饰）（Chemical Biology）
本课题组也感兴趣利用新颖的有机反应实现蛋白质的选择性修饰，并实现其功能的调控。
课题组主页：https://www.x-mol.com/groups/Yang_Xiaoyu
欢迎有志于以上研究领域的博士后、研究生以及本科生加入本课题组！
| 发表论文 (Publishcations) | |
After joining ShanghaiTech:
15. Yunrong Chen, Chaofan Zhu, Zheng Guo, Wei Liu, Xiaoyu Yang* Asymmetric Synthesis of Hydroquinolines with α,α-Disubstitution via Organocatalyzed Kinetic Resolution, Angew. Chem. Int. Ed., DOI: 10.1002/anie.202015008
14. Jiawen Wang#, Sujuan Zheng#, Subramani Rajkumar, Jinglei Xie, Na Yu, Qian Peng* and Xiaoyu Yang* Chiral phosphoric acid-catalyzed stereodivergent synthesis of trisubstituted allenes and computational mechanistic studies, Nat. Commun.2020, DOI: 10.1038/s41467-020-19294-8
13. Yongkai Pan, Qianwen Jiang, Subramani Rajkumar, Chaofan Zhu, Jinglei Xie, Shaoze Yu, Yunrong Chen, Yu-Peng He* and Xiaoyu Yang* Kinetic Resolution of 2-N-Acylamido Tertiary Allylic Alcohols: Asymmetric Synthesis of Oxazolines, Adv. Syn. Catal.2020, DOI: 10.1002/adsc.202001051
12. Wei Liu, Qianwen Jiang, Xiaoyu Yang*, Versatile Method for Kinetic Resolution of Protecting-Group-Free BINAMs and NOBINs through Chiral Phosphoric Acid Catalyzed Triazane Formation, Angew. Chem. Int. Ed., 2020, DOI: 10.1002/anie.202009395.
11. Xueqian Ye Yongkai Pan Yunrong Chen Xiaoyu Yang*, Enantioselective Construction of Sulfur‐Containing Tetrasubstituted Stereocenters via Asymmetric Functionalizations of α‐Sulfanyl Cyclic Ketones, Adv. Syn. Catal. 2020, 362, 3374-3379.
10. Shunlong He, Huanchao Gu, Yu-Peng He*, and Xiaoyu Yang*，Asymmetric Aza-Diels–Alder Reactions of in Situ Generated β,β-Disubstituted α,β-Unsaturated N–H Ketimines Catalyzed by Chiral Phosphoric Acids，Org. Lett., 2020, 22, 5633–5639.
9. Donglei Wang, Qianwen Jiang and Xiaoyu Yang*，Atroposelective synthesis of configurationally stable nonbiaryl N-C atropisomers through direct asymmetric aminations of 1,3-benzenediamines, Chem Commun, 2020, 56, 6201-6204. (Selected as “Chem Commun HOT Articles' by editors)
8. Subramani Rajkumar#, Mengyao Tang# and Xiaoyu Yang*, Chiral Phosphoric Acid-Catalyzed Kinetic Resolution of 2-Amido Benzyl Alcohols: Asymmetric Synthesis of 4H-3,1-Benzoxazines, Angew. Chem. Int. Ed. 2020, 59, 2333-2337.
7. Xueqian Ye, Yongkai Pan and Xiaoyu Yang*, Direct enantioselective Mannich reactions of α-azido cyclic ketones: asymmetric construction of chiral azides possessing an α-quaternary stereocenter, Chem. Commun. 2020, 56, 98-101.
6. Donglei Wang#, WeiLiu#, MengyaoTang, NaYu, XiaoyuYang*, Atroposelective Synthesis of Biaryl Diamines and Amino Alcohols via Chiral Phosphoric Acid Catalysed para-Aminations of Anilines and Phenols, iScience, 2019, 22, 195-205.
5. Subramani Rajkumar#, Shunlong He# and Xiaoyu Yang* Kinetic Resolution of Tertiary 2-Alkoxycarboxamido-allylic Alcohols by Chiral Phosphoric Acid Catalyzed Intramolecular Transesterification. Angew. Chem. Int. Ed. 2019, 58, 10315 –10319.
4. Wei Liu, Subramani Rajkumar, Weihu Wu, Ziyu Huang, and Xiaoyu Yang*, Asymmetric Synthesis of β-Indolyl Cyclopentanones and Cyclopentylamides with an All-Carbon Quaternary Stereocenter via Chiral Phosphoric Acid Catalyzed Friedel–Crafts Alkylation Reactions, Org. Lett. 2019, 21, 10, 3563-3567.
3. Subramani Rajkumar#, Jiawen Wang#, Xiaoyu Yang*, Asymmetric Transformations of α-Hydroxy Enamides Catalyzed by Chiral Br?nsted Acids, Synlett 2019, 30(08): 869-874 (invited synpact paper)
2. Subramani Rajkumar#, Jiawen Wang#, Sujuan Zheng, Donglei Wang, Xueqian Ye, Xuejiao Li, Qian Peng,* and Xiaoyu Yang*, Regioselective and Enantioselective Synthesis of β-Indolyl Cyclopentenamides by Chiral Anion Catalysis. Angew. Chem. Int. Ed. 2018, 57, 13489 –13494
1. Shixian Lin#; Xiaoyu Yang#, S. Jia, A.M. Weeks, M. Hornsby, P.S. Lee, R.V. Nichiporuk, A.T. Iavarone, J.A. Wells, F.D. Toste, C.J. Chang, Redox-based reagents for chemoselective methionine bioconjugation. Science 2017, 355, 597-602 (# contribute equally)
Selected works before joining ShanghaiTech:
Xiaoyu Yang and F. Dean Toste*. Asymmetric addition of α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid. Chem. Sci. 2016, 7, 2653-2656.
Xiaoyu Yang, F. Dean Toste*. Direct Asymmetric Amination of α-Branched Cyclic Ketones Catalyzed by a Chiral Phosphoric Acid. J. Am. Chem. Soc. 2015, 137, 3205-3208.
Xiaoyu Yang#, Tao Wu#, Robert J. Phipps, F. Dean Toste*.Advances in Catalytic Enantioselective Fluorination, Mono, Di, and Trifluoromethylation, and Trifluoromethylthiolation Reactions. Chem. Rev. 2015, 115, 826-870.
Xiaoyu Yang#, Robert J. Phipps#, F. Dean Toste*. Asymmetric Fluorination of α-Branched Ketones Enabled by a Synergistic Combination of Chiral Anion Phase-Transfer Catalysis and Enamine Catalysis using Protected Amino Acids. J. Am. Chem. Soc. 2014, 136, 5225-5228.
Xiaoyu Yang, Boqiao Fu, and Biao Yu*.Total Synthesis of Landomycin A, a Potent Antitumor Angucycline Antibiotic. J. Am. Chem. Soc. 2011, 133, 12433-12435.
| 组内活动和新闻 （Group Activities and News） | |
2020年11月 新场轰趴 | |
2020年6月 |
2019年4月滴水湖烧烤 |
2019年1月 |
2018年春节聚餐 |
2020年11月2日，恭喜 刘炜 获得2020年博士研究生国家奖学金！
| 本组成员（Group Members） | |
陈运荣 助理研究员 chenyr@shanghaitech.edu.cn |  郭政17级 博士研究生 guozheng@shanghaitech.edu.cn |  汪家文16级 硕博研究生 wangjw1@shanghaitech.edu.cn | |
 王东磊17级 硕博研究生 wangdl@shanghaitech.edu.cn |  张得坤18级 硕博研究生 zhangdk@shanghaitech.edu.cn |  唐梦瑶18级 硕博研究生 tangmy@shanghaitech.edu.cn |  何发仟18级 硕博研究生 hefq@shanghaitech.edu.cn |
 姜倩雯19级 硕士研究生 jiangqw@shanghaitech.edu.cn |  俞少泽19级 硕士研究生 yushz@shanghaitech.edu.cn |
秦天人20级 硕士研究生 qintr@shanghaitech.edu.cn |
叶子旦20级 硕士研究生 yezd@shanghaitech.edu.cn |
沈国嵩20级 硕士研究生 shengs@shanghaitech.edu.cn |
| 往届成员 （Alumni） | |
